Jejunal intussusception due to intestinal metastasis of cutaneous malignant melanoma: clinical case report.
DOI:
https://doi.org/10.31837/cir.urug/9.1.8Keywords:
Melanoma, metastasis, small bowel, intussusceptionAbstract
Melanoma is a malignant neoplasm that predominantly affects the skin and accounts for 1–3% of all neoplasms. It is characterized by its high metastatic potential, frequently involving the gastrointestinal tract, with the jejunum and ileum being the most commonly affected sites. Most patients with gastrointestinal metastases are asymptomatic or present with nonspecific symptoms. Complications are uncommon; among them, intestinal obstruction is notable, with intussusception being a rare form of presentation.
The aim of this report is to present the clinical case of a 63-year-old male patient with a previous diagnosis of cutaneous malignant melanoma who, two years later, presented with clinical and imaging findings consistent with intestinal obstruction. An emergency laparotomy was performed, revealing an intussusception at the jejunal level and a nodular mass in the mesentery. Segmental resection with anastomosis was carried out. Histopathological analysis confirmed cutaneous melanoma metastasis.
The early detection of gastrointestinal metastases presents a true diagnostic challenge. Given the high frequency of metastatic involvement of the jejunum and ileum, a high index of suspicion is essential in the presence of nonspecific symptoms such as abdominal pain, systemic compromise, and/or anemia. In such cases, diagnostic studies with greater accuracy such as positron emission tomography combined with computed tomography (PET-CT) and capsule endoscopy should be considered. Surgical treatment of gastrointestinal metastases has been shown to improve prognosis and increase survival, compared to patients with unresected metastatic disease.
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References
Amarillo D, De Boni D, Nantes F, Tambasco C, Brayer C, Palacios C, et al. Melanoma cuta?neo en Uruguay: caracteri?sticas cli?nico-epidemiolo?gicas y sobrevida en cohorte de pacientes de dos centros de referencia en el peri?odo 2008-2017. Rev Med Urug. 2020;36(2):146-54. doi: 10.29193/RMU.36.2.4
Cassina JC, Gallardo A, Valbuena JR, Martínez J. Intususcepción intestinal secundaria a metástasis de melanoma: caso clínico. Rev Chil Cir. 2011;63(2):194–9.
Yerrakalva D, Ackroyd R, Lee F. Metastatic malignant melanoma causing ileo-ileal intussusception. J Surg Case Rep. 2011;2011(12):1. doi:10.1093/jscr/2011.12.1
Santiago P. Afecciones quirúrgicas del yeyuno-íleon. Montevideo: Academia Nacional de Medicina; 2009. p. 37.
Romero L, Arcienega P, Telles L, Gonza?lez D. Melanoma metasta?sico en intestino delgado: causa infrecuente de perforacio?n: reporte de caso. Cir. Urug. 2023;7(1):1-6. doi: 10.31837/cir.urug/7.1.4
Kohoutova D, Worku D, Aziz H, Teare J, Weir J, Larkin J. Malignant melanoma of the gastrointestinal tract: symptoms, diagnosis, and current treatment options. Cells. 2021;10(2):327. doi:10.3390/cells1002032
Lens M, Bataille V, Krivokapic Z. Melanoma of the small intestine. Lancet Oncol. 2009;10(5):516-21. doi: 10.1016/S1470-2045(09)70036-1.
Cedron Cheng H, Aliaga Ramos J. Ca?psula endosco?pica para el diagno?stico de meta?stasis de melanoma en intestino delgado, reporte de dos casos y revisio?n de la literatura. Acta Gastroenterol Latinoam. 2020;50(1):50-6. doi: 10.52787/llbj9802
Mantas D, Tsaparas P, Charalampoudis P, Gogas H, Kouraklis G. Emergency surgery for metastatic melanoma. Int J Surg Oncol. 2014;2014:987170. doi: 10.1155/2014/987170
Pin?eyro A, Carriquiry L. Tumores metasta?sicos del yeyuno-i?leon. Cir. Urug. 2004;74(2):73-8. https://revista.scu.org.uy/index.php/cir_urug/article/view/4529
Othman A, Eigentler T, Bier G, Pfannenberg C, Bösmüller H, Thiel C, et al. Imaging of gastrointestinal melanoma metastases: correlation with surgery and histopathology of resected specimen. Eur Radiol. 2017;27(6):2538–45. doi:10.1007/s00330-016-4625-7
La Selva D, Kozarek RA, Dorer RK, Rocha FG, Gluck M. Primary and metastatic melanoma of the GI tract: clinical presentation, endoscopic findings, and patient outcomes. Surg Endosc. 2020;34(10):4456–62. doi: 10.1007/s00464-019-07225-8
?okic? M, Badovinac D, Petric? M, Trotovs?ek B. An unusual presentation of metastatic malignant melanoma causing jejuno-jejunal intussusception: a case report. J Med Case Rep. 2018;12(1):337. doi: 10.1186/s13256-018-1887-5.
Kharroubi H, Osman B, Kakati RT, Korman R, Khalife MJ. Metastatic melanoma to the small bowel causing intussusception: A case report. Int J Surg Case Rep. 2022;93:106916. doi: 10.1016/j.ijscr.2022.106916.
Yagmur Y, Ac??kgo?z MA. Metastatic melanoma causing recurrent intussusception and perforation of small bowel: case reports and literature review. Melanoma Manag. 2021;8(1):MMT54. doi: 10.2217/mmt-2020-0015.
Hong KD, Kim J, Ji W, Wexner SD. Adult intussusception: a systematic review and meta-analysis. Tech Coloproctol. 2019;23(4):315-324. doi: 10.1007/s10151-019- 01980-5.
Bender GN, Maglinte DD, McLarney JH, Rex D, Kelvin FM. Malignant melanoma: patterns of metastasis to the small bowel, reliability of imaging studies, and clinical relevance. Am J Gastroenterol. 2001;96(8):2392–400. doi: 10.1111/j.1572- 0241.2001.04041.x.
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